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Below are the publications this lab has been associated with. Click the links to open the publications in a new window.

High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo.
Claire S. Koechlein, Jeffrey R. Harris, Timothy Lee, Joi Weeks, Raymond G. Fox, Bryan Zimdahl, Takahiro Ito, Allen Blevins, Seung-Hye Jung, John P. Chute, Amit Chourasia, Markus Covert and Tannishtha Reya. 2016.
Nature Communications DOI:10.1038/ncomms12169
Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma
Raymond G. Fox, Nikki K. Lytle, Dawn V. Jaquish, Frederick D. Park, Takahiro Ito, Jeevisha Bajaj, Claire S. Koechlein, Bryan Zimdahl, Masato Yano, Janel L. Kopp, Marcie Kritzik, Jason K. Sicklick, Maike Sander, Paul M. Grandgenett, Michael A. Hollingsworth, Shinsuke Shibata, Donald Pizzo, Mark A. Valasek, Roman Sasik, Miriam Scadeng, Hideyuki Okano, Youngsoo Kim, A. Robert MacLeod, Andrew M. Lowy & Tannishtha Reya. 2016.
Nature DOI: 10.1038/nature17988
Leading Edge
Targeting Resistance
Jiaying Tan (2016) Cell 
Research Highlights
Pancreatic Cancer: A new model for imaging tumour progression
Ian Dickson (2016) Nature Reviews Gastroenterology & Hepatology 
Musashi Signaling in Stem Cells and Cancer
Raymond G. Fox, Frederick D. Park, Claire S. Koechlein, Marcie Kritzik, and Tannishtha Reya. 2015.
The Annual Review of Cell and Developmental Biology DOI: 10.1146/annurev-cellbio-100814-125446
Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia
Hyog Young Kwon, Jeevisha Bajaj, Takahiro Ito, Allen Blevins, Takaaki Konuma, Joi Weeks, Nikki K. Lytle, Claire S. Koechlein, David Rizzieri, Charles Chuah, Vivian G. Oehler, Roman Sasik, Gary Hardiman, Tannishtha Reya. 2015.
Cell Stem Cell DOI: 10.1016/j.stem.2015.06.006
Fearful Symmetry: Subversion of Asymmetric Division in Cancer Development and Progression
Jeevisha Bajaj, Bryan Zimdahl, and Tannishtha Reya. 2015.
Cancer Research DOI: 10.1158/0008-5472.CAN-14-2750
Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration
William Lento, Takahiro Ito, Chen Zhao, Jeffrey R. Harris, Wei Huang, Chen Jiang, Kouros Owzar, Sadhna Piryani, Luigi Racioppi, Nelson Chao and Tannishtha Reya. 2014.
Genes & Development doi: 10.1101/gad.231944.113
Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia
Zimdahl B, Ito T, Blevins A, Bajaj J, Konuma T, Weeks J, Koechlein CS, Kwon HY, Arami O, Rizzieri D, Broome HE, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T. 2014.
Nature Genetics doi: 10.1038/ng.2889
News and Views
Stem cell fate regulation by dynein motor protein Lis1
Britta Will and Ulrich Steidl (2014) Nature Genetics 
Wnt Signaling in Normal and Malignant Hematopoiesis
Lento W, Congdon K, Voermans C, Kritzik M, and Reya T. 2013
Cold Spring Harbor Perspectives in Biology 5(2). pii: a008011
aSIRTing control over cancer stem cells
Ito T, Zimdahl B and Reya T. 2012.
Cancer Cell 21(2):140-2
β-Arrestin2 mediates the initiation and progression of myeloid leukemia.
Fereshteh M, Ito T, Kovacs JJ, Zhao C, Kwon HY, Tornini V, Konuma T, Chem M, Lefkowitz RJ, and Reya T. 2012.
Proceedings of the National Academy of Sciences 109(31):12532-7
Illuminating immune privilege-a role for regulatory T cells in preventing rejection
Reya T. 2011.
New England Journal of Medicine 365(10):956-7
Regulation of myeloid leukaemia by the cell-fate determinant Musashi
Ito T, Kwon Y, Zimdahl B, Congdon K, Blum J, Lento W, Zhao C, Lagoo A, Gerrard G, Foroni L, Goldman J, Goh H, Kim S, Kim D, Chuah C, Oehler V, Radich J, Jordan C, & Reya T. 2010.
Nature 466(7307):765-8
Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
Kim J, Tang J, Gong R, Kim J, Lee J, Clemons K, Chong C, Chang K, Fereshteh M, Gardner D, Reya T, Liu J, Epstein E, Stevens D, & Beachy P. 2010.
Cancer Cell 17(4):388-99
Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells
Himburg H, Muramoto G, Daher P, Meadows S, Russell J, Doan P, Chi J, Salter A, Lento W, Reya T, Chao N, & Chute J. 2010.
Nature Medicine 16:475-82
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
Zhao C*, Chen A*, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J, Kwon HY, Kim J, Chute JP, Rizzieri D, Munchhof M, VanArsdale T, Beachy PA & Reya T. 2009.
Nature  458(7239):776-9
Research Highlights
Killing Hedgehog to treat CML
Chenette E (2009) Nature Reviews Cancer 
Research Highlights
Self-renewing blood and leukemia cells need hedgehog
Alves S (2009) Nature Reports Stem Cells 
Divide and Conquer: How asymmetric division shapes cell fate in the hematopoietic system
Congdon KL and Reya T. 2008.
Current Opinion In Immunology 20:302-7
Activation of Wnt signaling in hematopoietic regeneration
Congdon KL*, Voermans C*, Ferguson EC, DiMascio LN, Uqoezwa M, Zhao C and Reya T. 2008.
Stem Cells 26:1202-10
Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo.
Zhao C, Blum J, Chen A, Young HK, Jung SH, Cook MP, Lagoo A, and Reya T. 2007.
Cancer Cell. 12:528-541.
Knocking the Wnt out of the Sails of Leukemia Stem Cell Development.
Deshpande AJ and Buske C (2007) Cell Stem Cell, 1:597-598.
Imaging hematopoietic precursor division in real-time.
Wu MF, Kwon HY, Rattis FM, Blum J, Zhao C, Ashkenazi R, Jackson TL, Gaiano N, Oliver T and Reya T. 2007.
Cell Stem Cell, 1:541-554.
Asymmetric cell division in normal and malignant hematopoietic precursor cells.
Schroeder T (2007) Cell Stem Cell, 1:479-481.
Identification of Adiponectin As a Novel Hematopoietic Stem Cell Growth Factor.
DiMascio LN, Voermans C, Uqoezwa M, Duncan AW, Lu D, Wu J, Sankar U, and Reya T. 2007.
Journal of Immunology. 178(6):3511-3520.
Wnt signalling in stem cells and cancer.
Reya T and Clevers H. 2005
Nature. 434(7035):843-50.
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance.
Duncan AW*, Rattis FM*, Dimascio LN, Congdon KL, Pazianos G, Zhao C, Yoon K, Cook JM, Willert K, Gaiano N, and Reya T. 2005
Nature Immunology. 6(3):314-22.
News and Views
Defining 'stemness': Notch and Wnt join forces?
Jacobsen SE. (2005) Nature Immunology, 6(3):234-6.
Research Highlights
Notch balances self-renewal and differentiation.
Honey K. (2005) Nature Reviews Immunology, 5:184-185.
Wnt signaling in the stem cell niche.
Rattis FM, Voermans C, and Reya T. 2004.
Current Opinion in Hematology. 11(2):88-94.
The elements of stem cell self-renewal: a genetic perspective.
Pazianos G, Uqoezwa M, and Reya T. 2003
Biotechniques, 35(6):1240-7.
Wnt proteins are lipid-modified and can act as stem cell growth factors.
Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR 3rd, and Nusse R. 2003
Nature. 423(6938):448-52.
A role for Wnt signalling in self-renewal of haematopoietic stem cells.
Reya T*, Duncan AW*, Ailles L, Domen J, Scherer DC, Willert K, Hintz L, Nusse R, and Weissman IL. 2003
Nature. 423(6938):409-14.
Purified signaling protein stimulates stem cell proliferation.
Couzin J. (2003) Science, 300(5620):722.
News and Views
Manipulating hematopoietic stem cell amplification with Wnt.
Eaves CJ. (2003) Nature Immunology, 4(6):511-2.
Regulation of hematopoietic stem cell self-renewal.
Reya T. 2003
Recent Progress in Hormone Research, 58:283-95.
Stem cells, cancer, and cancer stem cells.
Reya T*, Morrison SJ*, Clarke MF, and Weissman IL. 2001
Nature, 414(6859):105-11.
Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism.
Reya T, O'Riordan M, Okamura R, Devaney E, Willert K, Nusse R, and Grosschedl R. 2001
Immunity, 13(1):15-24.
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